Effects of Thyroxine and Thiouracil on Induction of Skin Tumors in Mice by 9,10-Dimethyl-l,2-benzanthracene and Croton Oil* JOSEPHMEITES
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چکیده
Relatively few studies have been made of the influence of the thyroid gland on the development and growth of tumors. Lerman (15) stated that the thyroid does not greatly influence the onset and growth of either experimental or human cancer, but Rawson (17) recently cited some experimental and clinical observations which suggest that hyperthyroidism may inhibit, while hypothyroidism may enhance, tumor formation. Kreyberg (14) observed that thyroid adminis tration accelerated skin tumor formation in tarred mice, while Silverstone and Tannenbaum (20) found that thyroid extracts had little or no effect on benzpyrene-induced skin tumors in mice. Epitheliomatous proliferation in the rabbit's ear
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Induction of Skin Tumors in the Mouse with Minute Doses of 9,10-Dimethyl-l,2-benzanthracene Alone or with Croton Oil*
Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...
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Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...
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The skin of Swiss albino mice was exposed once to 0.16 #g. of 9,10-dimethyl-l ,~benzanthracene (DMBA) or 1,2,5,6-dibenzanthracene (DBA), followed by continuous t rea tment with croton oil. Other mice were exposed to 0.0~ ug. of the same carcinogens. Control mice were t reated once with acetone followed by continuous t r ea tmen t with croton oil. A higher incidence of skin tumors was observed f...
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The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...
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